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. 2007 Oct 31;129(43):12942-3.
doi: 10.1021/ja075768z. Epub 2007 Oct 10.

Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E Merritt  1 , Crystal Harrison, Zoltan Kovacs, Preeti Kshirsagar, Craig R Malloy, A Dean Sherry
Affiliations

Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E Merritt et al. J Am Chem Soc. .

Abstract

Hyperpolarization of 89YCl3 and three 89Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T1’s of 89Y make its application as an MR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of 89Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

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Figures

Figure 1
Figure 1
Figure 2
Figure 2
NMR signal of 89Y(DOTA)− collected as a function of time after the sample was ejected from the polarizer, then inserted into the magnet. Total time following dissolution until the first acquisition was 30 seconds. The pH was 7 and final concentration of Y(DOTA)− in the NMR tube was 7.9 mM. The fitted line gave a T1 of 499 seconds.
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