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Review
. 2007 Oct 9;4(10):e240.
doi: 10.1371/journal.pmed.0040240.

HCV-HIV coinfection: simple messages from a complex disease

Paul Klenerman  1 , Arthur Kim
Affiliations
Review

HCV-HIV coinfection: simple messages from a complex disease

Paul Klenerman et al. PLoS Med. .

Abstract

The authors discuss our current understanding of the immunopathogenesis of HCV-HIV coinfection.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: PK has acted as a consultant for Intercell AG.

Figures

Figure 1
Figure 1. Immunologic Control of HCV Pathogenesis
In a normal HCV monoinfection, HCV-specific CD4 and CD8 T cells are mobilized to contain infection. If infection is not cleared, such T cells contribute to antiviral effects, proinflammatory effects, and regulatory effects. There is emerging evidence that the high viral loads of HCV during coinfection with HIV are associated with profound defects in HCV-specific CD4 and also CD8 T cell responses. There are some data showing that the cytokine environment in the liver is altered, which could affect disease progression independently from any influence of virus load.
See this image and copyright information in PMC

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