Review
doi: 10.1152/physiol.00016.2007.
No potassium, no acid: K+ channels and gastric acid secretion
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- PMID: 17928547
- DOI: 10.1152/physiol.00016.2007
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Review
No potassium, no acid: K+ channels and gastric acid secretion
Physiology (Bethesda).
2007 Oct.
Free article
Abstract
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
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