doi: 10.1271/bbb.70229.
Epub 2007 Oct 7.
Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars
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- PMID: 17928698
- DOI: 10.1271/bbb.70229
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Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars
Biosci Biotechnol Biochem.
2007 Oct.
Free article
Abstract
The alpha-dicarbonyl compounds formed in the degradation of glucose and fructose were analyzed by HPLC using 2,3-diaminonaphthalene as derivatizing reagent, and identified as glucosone (GLUCO), 3-deoxyglucosone (3DG), 3-deoxyxylosone (3DX), tetrosone (TSO), triosone (TRIO), 3-deoxytetrosone (3DT), glyoxal (GO), and methylglyoxal (MGO). The results suggest that alpha-dicarbonyl compounds were formed from glucose via non-oxidative 3-deoxyglucosone formation and oxidative glucosone formation in glucose degradation. In addition, TRIO, GO, and MGO were also formed from glyceraldehyde as intermediate. The alpha-dicarbonyl compounds might be formed from glucose via these pathways in diabetes.
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