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. 2007 Oct;105(2):211-4.
doi: 10.1254/jphs.scz070901. Epub 2007 Oct 6.

Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira  1 , Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara
Affiliations
Free article

Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira et al. J Pharmacol Sci. 2007 Oct.
Free article

Abstract

We investigated the involvement of gamma-aminobutyric acid(A) (GABA(A)) receptors in the neuroprotective effect of gamma-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA(A)-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors.

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