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. 1991 Sep;34(1-2):203-4.
doi: 10.1007/BF01993279.

Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig

D Vincent  1 , J Lefort, M Bureau, J Dry, B B Vargaftig
Affiliations

Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig

D Vincent et al. Agents Actions. 1991 Sep.

Abstract

The interactions between LPS-induced bronchial hyper-reactivity (BHR) and lung inflammation (LI) were investigated. LPS-induced LI was assessed with the augmented alveolo-capillary permeability (ACP) and with the increased migration of neutrophils into the broncho-alveolar lavage fluid. BHR was defined as the increase in the response to a standard dose of serotonin. Mepyramine and the PAF antagonist WEB 2170 blocked LPS-induced increase of ACP, whereas aspirin was inactive. By contrast, neither LPS-induced neutrophil attraction to airways, nor LPS-induced HBR were inhibited by these agents. Our results indicate that LPS-induced edema and BHR are dissociated.

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