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. 1991 Sep;34(1-2):214-6.
doi: 10.1007/BF01993283.

Magnetic resonance imaging of the rabbit knee: detection of cartilage proteoglycan degradation

E M O'Byrne  1 , P K Paul, V Blancuzzi, D Wilson, D Gunson, J Z Wang, R S Mezrich, F L Douglas
Affiliations

Magnetic resonance imaging of the rabbit knee: detection of cartilage proteoglycan degradation

E M O'Byrne et al. Agents Actions. 1991 Sep.

Abstract

Intra-articular (i.a.) injection of papain causes a reversible loss of proteoglycan in intact rabbit knees. Twelve rabbits were scanned with magnetic resonance imaging (MRI) at 0, 24, 48 and 72 hours after 5 units of papain i.a. in a 1.5 Tesla Signa with a three inch surface coil using spin echo sequence. Total cartilage thickness in proton density images was 1.08 +/- 0.09 mm prior to papain injection. The magnetic resonance images showed a reduction in articular cartilage thickness in papain-treated rabbit femurs at 24 hours to 0.69 +/- 0.18 mm and partial restoration by 72 hours to 0.77 +/- 0.21 mm.

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