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. 1991 Sep;34(1-2):38-41.
doi: 10.1007/BF01993232.

Crystal-neutrophil interactions lead to interleukin-1 synthesis

C J Roberge  1 , J Grassi, R De Médicis, Y Frobert, A Lussier, P H Naccache, P E Poubelle
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Crystal-neutrophil interactions lead to interleukin-1 synthesis

C J Roberge et al. Agents Actions. 1991 Sep.

Abstract

Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals. These results suggest that neutrophil-derived IL-1 may contribute to the pathogenesis of crystal-induced arthritis.

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