doi: 10.1007/BF01993239.
The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats
Affiliations
- PMID: 1793053
- DOI: 10.1007/BF01993239
Item in Clipboard
The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats
Agents Actions.
1991 Sep.
Abstract
We have investigated the effects of recombinant rat gamma-interferon (rIFN gamma) on adjuvant-induced arthritis (AA). Lewis rats, inoculated in the left hind-paw with adjuvant (day 0), were given 10(5) U/rat of rIFN gamma daily (days 0 to 20), subcutaneously and intramuscularly on alternate days. rIFN gamma suppressed the secondary phase of swelling of both hind-paw on and after day 18 without influencing the earlier phases, both primary and secondary, of swelling. rIFN gamma also reduced the hind-paw bone lesions, the degree of splenomegaly, and the increase in erythrocyte sedimentation rate and plasma fibrinogen. These results indicate a new aspect of the regulatory role of IFN gamma in chronic inflammation.
Similar articles
-
Meloxicam: a potent inhibitor of adjuvant arthritis in the Lewis rat.Inflamm Res. 1995 Dec;44(12):548-55. doi: 10.1007/BF01757360. Inflamm Res. 1995. PMID: 8788236
-
Effect of alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), a new anti-inflammatory drug, on the established adjuvant arthritis in rats.Jpn J Pharmacol. 1986 Oct;42(2):181-7. doi: 10.1254/jjp.42.181. Jpn J Pharmacol. 1986. PMID: 3795622
-
Development of a rapid screen for detecting and differentiating immunomodulatory vs. anti-inflammatory compounds in rats.Agents Actions. 1991 Sep;34(1-2):254-6. doi: 10.1007/BF01993296. Agents Actions. 1991. PMID: 1793040
-
Effects of an antagonist of the bombesin/gastrin-releasing peptide receptor on complete Freund's adjuvant-induced arthritis in rats.Peptides. 2008 Oct;29(10):1726-31. doi: 10.1016/j.peptides.2008.05.031. Epub 2008 Jun 12. Peptides. 2008. PMID: 18590783
-
Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats.J Ethnopharmacol. 2016 Jul 1;187:42-8. doi: 10.1016/j.jep.2016.04.031. Epub 2016 Apr 22. J Ethnopharmacol. 2016. PMID: 27109342
Cited by
-
Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines.Cytokine. 2017 Oct;98:87-96. doi: 10.1016/j.cyto.2017.04.012. Epub 2017 Apr 25. Cytokine. 2017. PMID: 28438552 Free PMC article. Review.
-
The dynamics of articular leukocyte trafficking and the immune response to self heat-shock protein 65 influence arthritis susceptibility.J Clin Immunol. 2008 Sep;28(5):420-31. doi: 10.1007/s10875-008-9205-4. Epub 2008 May 15. J Clin Immunol. 2008. PMID: 18481159
-
Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma.Clin Immunol. 2008 Apr;127(1):98-106. doi: 10.1016/j.clim.2008.01.003. Epub 2008 Feb 13. Clin Immunol. 2008. PMID: 18276192 Free PMC article.
-
Regulation of autoimmune inflammation by pro-inflammatory cytokines.Immunol Lett. 2008 Oct 30;120(1-2):1-5. doi: 10.1016/j.imlet.2008.07.008. Epub 2008 Aug 9. Immunol Lett. 2008. PMID: 18694783 Free PMC article. Review.