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. 2007 Dec;18(12):2090-3.
doi: 10.1016/j.jasms.2007.09.004. Epub 2007 Sep 14.

First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer

Cheng Lin  1 , Raman Mathur, Kostantin Aizikov, Peter B O'Connor
Affiliations

First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer

Cheng Lin et al. J Am Soc Mass Spectrom. 2007 Dec.

Abstract

The construction and achievement of the first signal on a cryogenic Fourier-transform ion cyclotron resonance mass spectrometer (FTICR-MS) are reported here, demonstrating proof-of-concept of this new instrument design. Building the FTICR cell into the cold bore of a superconducting magnet provided advantages over conventional warm bore design. At 4.2 K, the vacuum system cryopumps itself, thus removing the requirement for a large bore to achieve the desired pumping speed for maintaining base pressure. Furthermore, because the bore diameter has been reduced, the amount of magnet wire needed to achieve high field and homogeneity was also reduced, greatly decreasing the cost/Tesla of the magnet. The current instrument implements an actively shielded 14-Tesla magnet of vertical design with an external matrix-assisted laser desorption/ionization (MALDI) source. The first signal was obtained by detecting the laser desorbed/ionized (LDI) C(60)(+*) ions, with the magnet at 7 Tesla, unshimmed, and the preamplifier mounted outside of the vacuum chamber at room temperature. A subsequent experiment done with the magnet at 14 Tesla and properly shimmed produced a C(60) spectrum showing approximately 350,000 resolving power at m/z approximately 720. Increased magnetic field strength improves many FTMS performance parameters simultaneously, particularly mass resolving power and accuracy.

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Figures

Figure 1
Figure 1
Cut-away view of the complete cryogenic FTMS.
Figure 2
Figure 2
First signal on cryogenic FTMS at 7 Tesla.
Figure 3
Figure 3
High resolution mass spectra of C60 at 14 Tesla.
See this image and copyright information in PMC

References

    1. Comisarow MB, Marshall AG. Fourier Transform Ion Cyclotron Resonance Spectroscopy. Chemical Physics Letters. 1974;25:282–283.
    1. Easterling ML, Mize TH, Amster IJ. Routine Part-per-Million Mass Accuracy for High-Mass Ions: Space-Charge Effects in MALDI FT-ICR. Analytical Chemistry. 1999;71:624–632. - PubMed
    1. Muddiman DC, Oberg AL. Statistical Evaluation of Internal and External Mass Calibration Laws Utilized in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Analytical Chemistry. 2005;77:2406–2414. - PubMed
    1. Zhang LK, Rempel D, Pramanik BN, Gross ML. Accurate Mass Measurements by Fourier Transform Mass Spectrometry. Mass Spectrometry Reviews. 2005;24:286–309.
    1. Kim S, Rodgers RP, Marshall AG. Truly “Exact” Mass: Elemental Composition can be Determined Uniquely from Molecular Mass Measurement at Similar to 0.1 mDa Accuracy for Molecules up to Similar to 500 Da. International Journal of Mass Spectrometry. 2006;251:260–265.

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