Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Nov;66 Suppl 3(Suppl 3):iii42-4.
doi: 10.1136/ard.2007.078972.

Joint remodelling in inflammatory disease

Georg Schett  1
Affiliations
Review

Joint remodelling in inflammatory disease

Georg Schett. Ann Rheum Dis. 2007 Nov.

Abstract

Bone and the immune system share multiple interactions. The skeleton harbours the bone marrow and provides the niche for development of haematopoietic cells including the immune system. The immune system provides cells as well as molecular signals, which regulate bone homeostasis. Understanding the cellular and molecular regulation of the tight interaction between bone and the immune system is crucial for understanding the changes of skeletal architecture during inflammation. Whereas a short and self-limited activation of the immune system has no clinically meaningful effect on bone, prolonged immune activation as found in chronic inflammatory disease inevitably leads to bone wasting.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Gough A K, Lilley J, Eyre S, Holder R L, Emery P. Generalized bone loss in patients with early rheumatoid arthritis. Lancet 199434423–27. - PubMed
    1. Schett G, Redlich K, Smolen J S. Inflammation‐induced bone loss in the rheumatic diseases. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th edn. USA: Lippincott Williams & Wilkins, 2006310–313.
    1. Card T, West J, Hubbard R, Logan R F. Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study. Gut 200453251–255. - PMC - PubMed
    1. Schett G, Kiechl S, Weger S, Mayr A, Oberhollenzer S.et al High‐sensitivity C‐reactive protein and risk of non‐traumatic fractures in the Bruneck Study. Arch Int Med 20061662495–2501. - PubMed
    1. Firestein G S. Evolving concepts of rheumatoid arthritis. Nature 2003423356–361. - PubMed

MeSH terms