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Comment
. 2007 Nov;127(11):2495-7.
doi: 10.1038/sj.jid.5700855.

IL-15 and psoriasis: another genetic link to Th17?

James T Elder  1
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Free article
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IL-15 and psoriasis: another genetic link to Th17?

James T Elder. J Invest Dermatol. 2007 Nov.
Free article

Abstract

Interleukin-15 (IL-15) is a pro-inflammatory cytokine expressed in several inflammatory disorders. Zhang et al. (2007, this issue) report a significant genetic association between IL-15 and psoriasis, which may involve increased stability of IL-15 mRNA. Among its several activities, IL-15 stimulates the expression of IL-17 by T-cells. Together with recent genetic and therapeutic evidence implicating IL-23, these findings suggest a genetic basis for Th17-mediated inflammation in psoriasis.

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