Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Summer;9(3):113-23.

Twenty Years of PSA: From Prostate Antigen to Tumor Marker

Gabriela De Angelis, Harry G Rittenhouse, Stephen D Mikolajczyk, L Blair Shamel, Axel Semjonow

Twenty Years of PSA: From Prostate Antigen to Tumor Marker

Gabriela De Angelis et al. Rev Urol. 2007 Summer.

Abstract

The measurement of prostate-specific antigen in serum is credited with dramatic advances in the early detection of men with prostatic carcinoma. This report summarizes the history of biochemical research and the current understanding and application of prostate-specific antigen in prostate cancer diagnostics.

Keywords: Human kallikrein; Immunoassays; Prostate cancer; Prostate-specific antigen.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of major expressions of human kallikreins in various tissues. Adapted from Yousef and Diamandis.
See this image and copyright information in PMC

References

    1. Ablin RJ. On the identification and characterization of prostate-specific antigen. Hum Pathol. 1993;24:811–812. - PubMed
    1. Ablin RJ. A retrospective and prospective overview of prostate-specific antigen. J Cancer Res Clin Oncol. 1997;123:583–594. - PubMed
    1. Hara M, Inoue T, Koyanagi Y. Preparation and immunoelectrophoretic assessment of antisera to human seminal plasma. Nippon Hoigaku Zasshi. 1966;20:365.
    1. Hara M, Koyanagi Y, Inoue T. Some physico-chemical characteristics of “-seminoprotein,” an antigenic component specific for human seminal plasma: forensic immunological study of body fluids and secretion (VII) Nippon Hoigaku Zasshi. 1971;25:322–324. - PubMed
    1. Sensabaugh GF. Isolation and characterization of a semen-specific protein from human seminal plasma: a potential new marker for semen identification. J Forensic Sci. 1978;23:106–115. - PubMed

LinkOut - more resources