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Review
. 2007 Dec;20(6):498-506.
doi: 10.1111/j.1600-0749.2007.00414.x.

ATF2 on the double - activating transcription factor and DNA damage response protein

Anindita Bhoumik  1 , Pablo Lopez-Bergami, Ze'ev Ronai
Affiliations
Review

ATF2 on the double - activating transcription factor and DNA damage response protein

Anindita Bhoumik et al. Pigment Cell Res. 2007 Dec.

Abstract

Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.

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Figures

Fig 1
Fig 1
an outline of inactive vs. active forms of ATF2 and signal transduction pathways that are required for transcriptional activation of ATF2 are shown.
Fig 2
Fig 2
outline of two major functions identified for ATF2 in transcription and DNA repair, and the signaling pathways engaged in their activation.
See this image and copyright information in PMC

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