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. 2007 Dec;40(4):333-7.
doi: 10.1016/j.jcv.2007.08.015. Epub 2007 Nov 1.

Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong

N Lee  1 , P K S Chan, I T Yu, K K Tsoi, G Lui, J J Y Sung, C S Cockram
Affiliations

Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong

N Lee et al. J Clin Virol. 2007 Dec.

Abstract

Background: The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown.

Objectives: To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic.

Study design and methods: All available nasopharyngeal aspirate (NPA) collected from confirmed patients during the first 8 weeks of the SARS outbreak in 2003 were tested for hMPV by a nested RT-PCR assay targeting the F-gene. Clinico-epidemiological information was used to analyze the relationship of hMPV co-infection to specific risk factors (demographics/symptoms/outcomes; status as health-care workers (HCWs)/patients; history of exposure/contact; ward location). Multivariate logistic regression analysis was performed to determine independent risk factors.

Results: An hMPV outbreak occurred during 6-16 March 2003 (first week of the Hong Kong SARS epidemic). hMPV RNA was detected in 31 of 155 (20%) NPAs from SARS patients. HCW status (OR 2.72, 95% CI 1.11-6.68; p=0.029) or epidemiological linkage to the SARS outbreak ward (OR 3.59, 95% CI 1.42-9.05; p=0.007) were independent factors associated with hMPV infection. Symptoms of cough and coryza were more common in co-infected individuals (22.6% vs. 15.9%) but this was not statistically significant. Other clinical manifestations and outcomes were not different in co-infected patients.

Conclusions: A major nosocomial hMPV outbreak involving HCWs occurred during the early SARS epidemic. Patients with dual hMPV and SARS infection were not sicker than those with SARS infection only.

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Figures

Fig. 1
Fig. 1
Epidemic curves for SARS-CoV/hMPV co-infected patients (upper panel), and SARS patients tested negative for hMPV (lower panel). SARS-CoV: severe acute respiratory syndrome-associated cornoavirus; hMPV: human metapneumovirus.
See this image and copyright information in PMC

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