Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jan 1;16(1):530-5.
doi: 10.1016/j.bmc.2007.09.014. Epub 2007 Sep 14.

Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation

Kwangwoo Chun  1 , Song-Kyu Park, Hwan Mook Kim, Yongseok Choi, Myung-Hwa Kim, Chun-Ho Park, Bo-Young Joe, Tae Gyu Chun, Hyun-Moo Choi, Hee-Yoon Lee, Sung Hee Hong, Myung Sook Kim, Ky-Youb Nam, Gyoonhee Han
Affiliations

Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation

Kwangwoo Chun et al. Bioorg Med Chem. .

Abstract

A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources