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. 2007 Sep;27(4):241-5.

[Functional proteome analysis of human platelets]

[Article in German]
U Lewandrowski  1 , R P Zahedi, J Moebius, A Sickmann
Affiliations
  • PMID: 17938761

[Functional proteome analysis of human platelets]

[Article in German]
U Lewandrowski et al. Hamostaseologie. 2007 Sep.

Abstract

Platelets are anucleated cells and therefore ideal research objects for modern proteome analyses. Despite their importance in thrombosis and hemostasis the protein content of platelets is still poorly characterized in major parts. In preparation for bioinformatic and functional studies a series of proteomic analyses was conducted for platelet subproteomes as well as for posttranslational modifications. Thereby, the identification of 489 proteins, over 550 phosphorylations and 326 N-glycosylation sites was possible, which were not identified in previous proteome studies of platelets. Those results represent new research possibilities for functional characterization of platelet proteins as well as their modifications.

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