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Comment

. 2007 Oct 23;104(43):16725-6.

doi: 10.1073/pnas.0708151104. Epub 2007 Oct 16.

Bringing the genetics of macular degeneration into focus

Jonathan L Haines¹, Kylee M Spencer, Margaret A Pericak-Vance

Affiliations

PMID: 17940012
PMCID: PMC2040461
DOI: 10.1073/pnas.0708151104

Comment

Bringing the genetics of macular degeneration into focus

Jonathan L Haines et al. Proc Natl Acad Sci U S A. 2007.

. 2007 Oct 23;104(43):16725-6.

doi: 10.1073/pnas.0708151104. Epub 2007 Oct 16.

Authors

Jonathan L Haines¹, Kylee M Spencer, Margaret A Pericak-Vance

Affiliation

¹ Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

PMID: 17940012
PMCID: PMC2040461
DOI: 10.1073/pnas.0708151104

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Five genes with common variation that alter the risk of developing AMD have been identified, with three implicating the complement system (Left) in the genetic etiology of AMD. With the data presented by Kanda et al. (2), oxidative stress (Right) is a second pathway implicated in the genetic etiology of AMD.

See this image and copyright information in PMC

Comment on

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.
Kanda A, Chen W, Othman M, Branham KE, Brooks M, Khanna R, He S, Lyons R, Abecasis GR, Swaroop A. Kanda A, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16227-32. doi: 10.1073/pnas.0703933104. Epub 2007 Sep 20. Proc Natl Acad Sci U S A. 2007. PMID: 17884985 Free PMC article.

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