Review
doi: 10.1586/14789450.4.5.667.
Postgenomics of Neisseria meningitidis for vaccines development
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- PMID: 17941821
- DOI: 10.1586/14789450.4.5.667
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Review
Postgenomics of Neisseria meningitidis for vaccines development
Expert Rev Proteomics.
2007 Oct.
Abstract
Meningococcal disease is a global problem. Multivalent (A, C, Y, W135) conjugate vaccines have been developed and licensed; however, an effective vaccine against serogroup B has not yet become available. Outer membrane vesicle (OMV) vaccines have been used to disrupt serogroup B epidemics and outbreaks. Postgenomic technologies have been useful in aiding the discovery of new protein vaccine candidates. Moreover, proteomic technologies enable large-scale identification of membrane and surface-associated proteins, and provide suitable methods to characterize and standardize the antigen composition of OMV-based vaccines.
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