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. 2007 Oct 17:7:89.
doi: 10.1186/1471-2180-7-89.

BACTIBASE: a new web-accessible database for bacteriocin characterization

Riadh Hammami  1 , Abdelmajid Zouhir, Jeannette Ben Hamida, Ismail Fliss
Affiliations

BACTIBASE: a new web-accessible database for bacteriocin characterization

Riadh Hammami et al. BMC Microbiol. .

Abstract

Background: Bacteriocins are very diverse group of antimicrobial peptides produced by a wide range of bacteria and known for their inhibitory activity against various human and animal pathogens. Although many bacteriocins are now well characterized, much information is still missing or is unavailable to potential users. The assembly of such information in one central resource such as a database would therefore be of great benefit to the exploitation of these bioactive molecules in the present context of increasing antibiotic resistance and natural bio-preservation need.

Description: In the present paper, we present the development of a new and original database BACTIBASE that contains calculated or predicted physicochemical properties of 123 bacteriocins produced by both Gram-positive and Gram-negative bacteria. The information in this database is very easy to extract and allows rapid prediction of relationships structure/function and target organisms of these peptides and therefore better exploitation of their biological activity in both the medical and food sectors.

Conclusion: The BACTIBASE database is freely available at http://bactibase.pfba-lab.org, web-based platform enabling easy retrieval, via various filters, of sets of bacteriocins that will enable detailed analysis of a number of microbiological and physicochemical data.

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Figures

Figure 1
Figure 1
Histogram of the distribution of peptide length in the BACTIBASE database.
Figure 2
Figure 2
Correlation between length and number of glycine residues among peptides in the BACTIBASE database.
Figure 3
Figure 3
Histogram of the distribution of cysteine residues among peptides in the BACTIBASE database.
Figure 4
Figure 4
Histogram of the distribution of the net charge among peptides in the BACTIBASE database.
Figure 5
Figure 5
Bar graph of the distribution of acidic and basic amino acids among peptides in the BACTIBASE database.
See this image and copyright information in PMC

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