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Multicenter Study
. 2007 Oct 17:8:60.
doi: 10.1186/1471-2296-8-60.

Use of aspirin for primary and secondary prevention of cardiovascular disease in diabetic patients in an ambulatory care setting in Spain

Antoni Sicras-Mainar  1 , Ruth Navarro-Artieda, Javier Rejas-Gutiérrez, Jaime Fernández-de-Bobadilla, Xavier Frías-Garrido, Rafael Ruiz-Riera
Affiliations
Multicenter Study

Use of aspirin for primary and secondary prevention of cardiovascular disease in diabetic patients in an ambulatory care setting in Spain

Antoni Sicras-Mainar et al. BMC Fam Pract. .

Abstract

Background: This study was conducted in order to determine the use of aspirin and to assess the achievement of therapeutic targets in diabetic patients according to primary (PP) or secondary prevention (SP).

Methods: This is a retrospective, observational study including patients > or =18 years with diabetes mellitus followed in four primary care centers. Measurements included demographics, use of aspirin and/or anticoagulant drugs, co-morbidities, clinical parameters and proportion of patient at therapeutic target (TT). Descriptive statistics, chi-square test and logistic regression model were used for significance.

Results: A total of 4,140 patients were analyzed, 79.1% (95% confidence intervals [CI]: 77.7-80.5%) in PP and 20.9% (95% CI: 18.2-23.7%) in SP. Mean age was 64.1 (13.8) years, and 49.3% of patient were men (PP: 46.3, SP: 60.7, p = 0.001). Aspirin was prescribed routinely in 20.8% (95% CI: 19.4-22.2%) in PP and 60.8% (95% CI: 57.6-64.0%) in SP. Proportion of patient at TT was 48.0% for blood pressure and 59.8% for cholesterol. Use of aspirin was associated to increased age [OR = 1.01 (95% CI: 1.00-1.02); p = 0.011], cardiovascular-risk factors [OR = 1.14 (95% CI: 1.03-1.27); p = 0.013], LDL-C [OR = 1.42 (95% CI: 1.06-1.88); p = 0.017] and higher glycated hemoglobin [OR = 1.51 (95% CI: 1.22-1.89); p = 0.000] were covariates associated to the use of aspirin in PP.

Conclusion: Treatment with aspirin is underused for PP in patients with diabetes mellitus in Primary Care. Achievement of TT should be improved.

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Figures

Figure 1
Figure 1
Distribution of the number of cardiovascular risk factors (CVRFs) associated to patients in primary or secondary prevention.
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References

    1. Mudaliar S. Intense management of diabetes mellitus: role of glucose control and antiplatelet agents. J Clin Pharmacol. 2004;44:414–22. doi: 10.1177/0091270004263045. - DOI - PubMed
    1. Nobles-James C, James EA, Sowers JR. revention of cardiovascular complications of diabetes mellitus by aspirin. Cardiovasc Drug Rev. 2004;22:215–26. - PubMed
    1. American Diabetes Association Aspirin therapy in diabetes. Diabetes Care. 2004;27:S72–S3. doi: 10.2337/diacare.27.2007.S72. - DOI - PubMed
    1. ETDRS Investigators Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. JAMA. 1992;268:1292–300. doi: 10.1001/jama.268.10.1292. - DOI - PubMed
    1. Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, Menard J, Rahn KH, Wedel H, Westerling S. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351:1755–62. doi: 10.1016/S0140-6736(98)04311-6. - DOI - PubMed

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