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Review
. 2007 Nov;7(11):847-59.
doi: 10.1038/nrc2223.

The emerging roles of forkhead box (Fox) proteins in cancer

Stephen S Myatt  1 , Eric W-F Lam
Affiliations
Review

The emerging roles of forkhead box (Fox) proteins in cancer

Stephen S Myatt et al. Nat Rev Cancer. 2007 Nov.

Abstract

Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.

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Comment in

  • FOXM1: the Achilles' heel of cancer?
    Radhakrishnan SK, Gartel AL. Radhakrishnan SK, et al. Nat Rev Cancer. 2008 Mar;8(3):c1; author reply c2. doi: 10.1038/nrc2223-c1. Nat Rev Cancer. 2008. PMID: 18297053 No abstract available.

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