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. 2007 Nov 20;428(1):17-20.
doi: 10.1016/j.neulet.2007.09.036. Epub 2007 Sep 26.

A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects

Ryota Hashimoto  1 , Hiroko Noguchi, Hiroaki Hori, Kazutaka Ohi, Yuka Yasuda, Masatoshi Takeda, Hiroshi Kunugi
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A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects

Ryota Hashimoto et al. Neurosci Lett. .

Abstract

Catechol-O-methyltransferase (COMT) is an enzyme that degrades various biogenic amines, which have been hypothesized to be associated with personality traits. We investigated a possible relationship between the COMT Val158Met polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) in 139 healthy subjects in a Japanese population. The number of Met alleles of the COMT Val/Met genotype tended to relate to harm avoidance (HA) scores parametrically, while no significant difference was observed between genotype groups in either novelty seeking, reward dependence, persistence, self-directedness, cooperativeness or self-transcendence. These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population.

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