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. 2007 Oct;14(7):383-92.
doi: 10.1155/2007/401795.

Canada's contribution to respiratory physiology and pathophysiology

Peter T Macklem  1
Affiliations

Canada's contribution to respiratory physiology and pathophysiology

Peter T Macklem. Can Respir J. 2007 Oct.
No abstract available

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Figures

Figure 1)
Figure 1)
The subdivisions of lung volume as described by Ronald Christie in 1932. Reproduced with permission from reference
Figure 2)
Figure 2)
A Ronald Christie’s measurements of pleural pressure in a normal subject sitting upright and supine. B Pleural pressure in a normal subject during a deep inspiration to total lung capacity followed by a breath out to residual volume. Both figures are reproduced with permission from reference
Figure 3)
Figure 3)
Ronald Christie’s tracings of pleural pressure in a patient with congestive heart failure. Note that tidal pressure swings, closely in phase with tidal volumes of approximately 360 mL, are approximately 30 cm H2O giving a dynamic compliance of only 0.012 L/cm H2O. To my knowledge, this is the first demonstration of stiff lungs in heart failure. Reproduced with permission from reference
Figure 4)
Figure 4)
Reuben Cherniack’s dynamic pressure-volume loops measured before and after bronchodilators in a patient with emphysema and cor pulmonale. Reproduced with permission from reference
Figure 5)
Figure 5)
Reuben Cherniack’s and Henry Levison’s classic diagram showing that the oxygen (O2) cost of breathing was a large component of total body O2 consumption during exercise in patients with chronic obstructive pulmonary disease. Means and standard errors are shown. Reproduced with permission from reference . VO2 Oxygen uptake; VE Minute ventilation
Figure 6)
Figure 6)
Milic-Emili’s famous onion skin diagram. Reproduced with permission from reference . D Distance; FRC Functional residual capacity; RV Residual volume; TLC Total lung capacity; TLCr Regional total lung capacity; V Overall lung volume; VC Vital capacity; Vr Regional lung volume
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References

    1. Christie RV. The lung volume and its subdivisions: I. Methods of measurement. J Clin Invest. 1932;11:1099–118. - PMC - PubMed
    1. Christie RV, McIntosh CA. The measurement of the intrapleural pressure in man and its significance. J Clin Invest. 1934;13:279–94. - PMC - PubMed
    1. Christie RV. The elastic properties of the emphysematous lung and their clinical significance. J Clin Invest. 1934;13:295–321. - PMC - PubMed
    1. Christie RV, Meakins JC. The intrapleural pressure in congestive heart failure and its clinical significance. J Clin Invest. 1934;13:323–45. - PMC - PubMed
    1. Christie RV, Eldridge FL, McIlroy MB, Thomas JP. The effect of added elastic and non-elastic resistances on the pattern of breathing in normal subjects. Clin Sci (Lond) 1956;15:337–44. - PubMed

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