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. 2007 Nov 14;13(42):5648-53.
doi: 10.3748/wjg.v13.i42.5648.

Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin

Roland El Braks  1 , Nathalie Ganne-Carrie, Helene Fontaine, Jacques Paries, Veronique Grando-Lemaire, Michel Beaugrand, Stanislas Pol, Jean-Claude Trinchet
Affiliations

Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin

Roland El Braks et al. World J Gastroenterol. .

Abstract

Aim: To assess the long-term clinical benefit of sustained virological response (SVR) in patients with hepatitis C virus (HCV) cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.

Methods: One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis, treated by at least one course of antiviral treatment > or = 3 mo and followed > or = 30 mo were included. The occurrence of linical events [hepatocellular carcinoma (HCC), decompensation and death] was compared in SVR and non SVR patients.

Results: Seventy eight patients received bitherapy and 63 had repeat treatments. SVR was achieved in 37 patients (33%). During a mean follow-up of 7.7 years, clinical events occurred more frequently in non SVR than in SVR patients, with a significant difference for HCC (24/76 vs 1/37, P = 0.01). No SVR patient died while 20/76 non-SVR did (P = 0.002), mainly in relation to HCC (45%).

Conclusion: In patients with HCV-related cirrhosis, SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years. This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis.

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Figures

Figure 1
Figure 1
Incidence of ascites or encephalopathy or gastrointestinal haemorrhage from the beginning of the first treatment according to the response to antiviral treatment (SVR: Sustained virological response in dotted line; non-SVR in full line; Log-Rank, P = 0.44).
Figure 2
Figure 2
Incidence of hepatocellular carcinoma from the beginning of the first treatment according to response to antiviral treatment. SVR: Sustained virological response in dotted line; Non-SVR in full line; Log-Rank, P = 0.01.
Figure 3
Figure 3
Incidence of death from the beginning of the first treatment according to response to antiviral treatment. SVR: Sustained virological response in dotted line; Non-SVR in full line; Log-Rank, P = 0.002.
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