doi: 10.1021/ol7022104.
Epub 2007 Oct 20.
Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines
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- PMID: 17949100
- DOI: 10.1021/ol7022104
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Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines
Org Lett.
.
Abstract
The reaction of the dienolate of ethyl acetoacetate (and related dienolates) with a range of 1,2- and 1,3-cyclic sulfamidates provides an entry to substituted and enantiopure alkylidenated pyrrolidines and piperidines. These heterocycles function as convenient precursors to heterocyclic beta-amino acid derivatives.
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