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. 2007 Nov 8;9(23):4909-12.
doi: 10.1021/ol7022104. Epub 2007 Oct 20.

Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines

John F Bower  1 , Peter Szeto, Timothy Gallagher
Affiliations

Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines

John F Bower et al. Org Lett. .

Abstract

The reaction of the dienolate of ethyl acetoacetate (and related dienolates) with a range of 1,2- and 1,3-cyclic sulfamidates provides an entry to substituted and enantiopure alkylidenated pyrrolidines and piperidines. These heterocycles function as convenient precursors to heterocyclic beta-amino acid derivatives.

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