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Review
. 2007;45(3):159-63.

Regulatory role of cathepsin D in apoptosis

Alina Minarowska  1 , Lukasz Minarowski, Alicja Karwowska, Marek Gacko
Affiliations
  • PMID: 17951163
Free article
Review

Regulatory role of cathepsin D in apoptosis

Alina Minarowska et al. Folia Histochem Cytobiol. 2007.
Free article

Abstract

Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper.

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