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Case Reports
. 1991 Sep;105(1):67-72.
doi: 10.1016/0022-510x(91)90120-v.

In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis

P J Poels  1 , E M Joosten, R C Sengers, A M Stadhouders, J H Veerkamp, A A Benders
Affiliations
Case Reports

In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis

P J Poels et al. J Neurol Sci. 1991 Sep.

Abstract

A few cases of non-anaesthetic-induced rhabdomyolysis in humans, predisposed to malignant hyperthermia (MH), have been described in literature. We studied a group of 6 consecutive patients with unexplained and recurrent attacks of rhabdomyolysis with the test used to determine susceptibility to MH, the in vitro contraction test (IVCT). The results of the IVCT showed 5 of these 6 patients to be MH susceptible. In cultured muscle cells from one of these patients a disturbed calcium homeostasis could be demonstrated. The relation between MH and recurrent rhabdomyolysis is discussed.

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