Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Feb 1;153(2):211-5.
doi: 10.1042/bj1530211.

Chemistry of the collagen cross-links. Nature of the cross-links in the polymorphic forms of dermal collagen during development

A J Bailey, T J Sims

Chemistry of the collagen cross-links. Nature of the cross-links in the polymorphic forms of dermal collagen during development

A J Bailey et al. Biochem J. .

Abstract

Both the type I and type III collagens present in embryonic dermis are stabilized by the intermolecular cross-link, hydroxylysino-5-oxonorleucine, derived from hydroxylysine-aldehyde, although the type I collagen possesses a significant proportion of dehydrohydroxylysinonorleucine. However, concurrent with the change in the proportion of the two types of collagen during postnatal development there is a change-over with both type I and III collagens to the labile cross-link, dehydrohydroxylysinonorleucine, derived from lysine aldehyde. The results indicate that the change in the nature of the cross-link with development is determined primarily by the change in the extent of hydroxylation of the lysine residues in the terminal non-helical regions rather than being due to the change in the type of collagen.

PubMed Disclaimer

References

    1. Biochem J. 1974 May;139(2):461-8 - PubMed
    1. J Biol Chem. 1974 May 25;249(10):3225-31 - PubMed
    1. Clin Chim Acta. 1973 Aug 30;47(2):289-94 - PubMed
    1. Science. 1974 Mar;183(130):1200-1 - PubMed
    1. Biochem Biophys Res Commun. 1971 Apr 16;43(2):340-5 - PubMed