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Randomized Controlled Trial
. 2007 Oct;71(4):249-55.

Monitoring blood glucose levels in female mink during the reproductive cycle: 2. Effects of short-term fish oil, chromium picolinate, and acetylsalicylic acid supplementation during late lactation

Amber M J Hynes  1 , Kirsti Rouvinen-Watt
Affiliations
Randomized Controlled Trial

Monitoring blood glucose levels in female mink during the reproductive cycle: 2. Effects of short-term fish oil, chromium picolinate, and acetylsalicylic acid supplementation during late lactation

Amber M J Hynes et al. Can J Vet Res. 2007 Oct.

Abstract
in English, French

Mink nursing sickness is a metabolic disorder characterized by hyperglycemia that is similar to the metabolic syndrome associated with type 2, or non-insulin-dependent, diabetes mellitus. This research studied the effects of short-term administration of antidiabetic supplements on the blood glucose concentration in female mink during late lactation. Female mink that had blood glucose levels < 5.5 mmol/L (normoglycemic [NG]) or > or = 5.5 mmol/L (hyperglycemic [HG]) early in lactation were given daily supplements of various combinations of herring oil (HerO, 3% in diet), chromium picolinate (CrPic, 200 microg), and acetylsalicylic acid (ASA, 100 mg) for 1 wk starting at day 21 post partum. In the NG mink, most of the treatments did not significantly change the blood glucose concentration from day 28 to 42 post partum. However, treatment with ASA alone and treatment with the combination HerO-CrPic-ASA elevated the blood glucose levels when compared with those of the control group, which had received just the basal diet. In the HG mink, all treatment combinations except CrPic alone and ASA alone, reduced the blood glucose concentration. Thus, in lactating mink with hyperglycemia, the blood glucose concentration may be effectively lowered by dietary antidiabetic supplementation; however, because hyperglycemia also occurs before nursing, preventive measures are recommended throughout the year.

Chez le vison la maladie de l’allaitement est un désordre métabolique caractérisé par une hyperglycémie et est similaire au syndrome métabolique associé avec le diabète mellitus de type 2, dit non insulino-dépendant. Au cours du présent projet on a étudié les effets d’une administration de courte durée d’un supplément anti-diabète sur la glycémie de visons femelles tard dans la période de lactation. Les visons femelles qui avaient des niveaux de glucose sanguin < 5,5 mmol/L (normoglycémique [NG]) ou ≥ 5,5 mmol/L (hyperglycémique [HG]) tôt dans la période de lactation ont reçu un supplément quotidien de différentes combinaisons d’huile de hareng (HerO; 3 % dans la diète), de picolinate de chrome (CrPic; 200 μg) et d’acide acétylsalicylique (ASA; 100 mg) durant 1 semaine débutant au jour 21 de la lactation. Chez les visons NG, la plupart des traitements n’ont pas modifié de manière significative la glycémie entre les jours 28 à 42 de la lactation. Toutefois, un traitement avec de l’ASA seule et un traitement avec la combinaison HerO-CrPic-ASA ont fait augmenter les niveaux de glucose sanguin comparativement à ceux du groupe témoin, qui n’avaient reçu qu’une diète de base. Chez les visons HG, toutes les combinaisons de traitement excepté celui de CrPic seul et celui d’ASA seule ont réduit la glycémie. Ainsi, chez les visons en lactation avec hyperglycémie, la concentration de glucose sanguin peut être réduite efficacement par une supplémentation alimentaire anti-diabétique; toutefois, étant donné que l’hyperglycémie se produit également avant l’allaitement, des mesures préventives sont recommandées durant toute l’année.

(Traduit par Docteur Serge Messier)

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Figures

Figure 1
Figure 1
Mean (least-squares) blood glucose levels, with standard errors, averaged over days 28 to 42 of lactation, for normoglycemic mink females fed the basal, control diet (CTRL) or the basal diet plus various combinations of herring oil (HerO), chromium picolinate (CrPic), and acetylsalicylic acid (ASA) for 1 wk from day 21. Means with the same letter(s) are not significantly different, as determined with transformed data (P < 0.05). Broken line indicates the cutoff point for normoglycemia (5.5 mmol/L).
Figure 2
Figure 2
Mean blood glucose levels for hyperglycemic mink females receiving the same experimental dietary treatments. Details as for Figure 1.
Figure 3
Figure 3
Mean comet assay score on day 42 of lactation in the entire study group of mink females.
See this image and copyright information in PMC

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