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. 2007 Oct 19;131(2):223-5.
doi: 10.1016/j.cell.2007.10.005.

A backup DNA repair pathway moves to the forefront

André Nussenzweig  1 , Michel C Nussenzweig
Affiliations
Free article

A backup DNA repair pathway moves to the forefront

André Nussenzweig et al. Cell. .
Free article

Abstract

Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal translocations of lymphoid cancers (Corneo et al., 2007; Soulas-Sprauel et al., 2007; Yan et al., 2007).

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