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. 2008 Oct;43(10):2178-88.
doi: 10.1016/j.ejmech.2007.08.007. Epub 2007 Sep 11.

Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins

Rajesh G Kalkhambkar  1 , Geeta M Kulkarni, Chandrappa M Kamanavalli, N Premkumar, S M B Asdaq, Chung Ming Sun
Affiliations

Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins

Rajesh G Kalkhambkar et al. Eur J Med Chem. 2008 Oct.

Abstract

A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.

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