Review
doi: 10.1016/j.pnpbp.2007.09.011.
Epub 2007 Sep 21.
Withania somnifera: an Indian ginseng
Affiliations
- PMID: 17959291
- DOI: 10.1016/j.pnpbp.2007.09.011
Item in Clipboard
Review
Withania somnifera: an Indian ginseng
Prog Neuropsychopharmacol Biol Psychiatry.
.
Abstract
Withania somnifera, popularly known as Ashwagandha is widely considered as the Indian ginseng. In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity. Having wide range of activity, it is used to treat almost all disorders that affect the human health. The present review discusses the pharmacological basis of the use of W. somnifera in various central nervous system (CNS) disorders, particularly its indication in epilepsy, stress and neurodegenerative diseases such as Parkinson's and Alzheimer's disorders, tardive dyskinesia, cerebral ischemia, and even in the management of drug addiction.
Similar articles
-
Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.Cent Nerv Syst Agents Med Chem. 2010 Sep 1;10(3):238-46. doi: 10.2174/1871524911006030238. Cent Nerv Syst Agents Med Chem. 2010. PMID: 20528765 Review.
-
Neurodegenerative diseases and Withania somnifera (L.): An update.J Ethnopharmacol. 2020 Jun 28;256:112769. doi: 10.1016/j.jep.2020.112769. Epub 2020 Mar 30. J Ethnopharmacol. 2020. PMID: 32240781 Review.
-
Withania somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and its Progress in Delivery Systems.Curr Drug Metab. 2021;22(7):561-571. doi: 10.2174/1389200222666210203182716. Curr Drug Metab. 2021. PMID: 33538666 Review.
-
Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis.Phytomedicine. 2018 Nov 15;50:247-256. doi: 10.1016/j.phymed.2017.11.011. Epub 2017 Nov 29. Phytomedicine. 2018. PMID: 30466985
-
Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats.Fundam Clin Pharmacol. 2007 Apr;21(2):157-64. doi: 10.1111/j.1472-8206.2006.00461.x. Fundam Clin Pharmacol. 2007. PMID: 17391288
Cited by
-
Neuroprotective Effects of Withania somnifera on 4-Hydroxynonenal Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells Through ROS Inhibition and Apoptotic Mitochondrial Pathway.Neurochem Res. 2021 Feb;46(2):171-182. doi: 10.1007/s11064-020-03146-4. Epub 2020 Oct 14. Neurochem Res. 2021. PMID: 33052512
-
Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.Toxins (Basel). 2016 May 12;8(5):147. doi: 10.3390/toxins8050147. Toxins (Basel). 2016. PMID: 27187469 Free PMC article.
-
Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells.Antioxidants (Basel). 2022 Sep 6;11(9):1761. doi: 10.3390/antiox11091761. Antioxidants (Basel). 2022. PMID: 36139835 Free PMC article.
-
Comparative evaluation of natural neuroprotectives and their combinations on chronic immobilization stress-induced depression in experimental mice.3 Biotech. 2023 Jan;13(1):22. doi: 10.1007/s13205-022-03438-2. Epub 2022 Dec 22. 3 Biotech. 2023. PMID: 36568496 Free PMC article.
-
A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.Medicine (Baltimore). 2023 Oct 13;102(41):e35521. doi: 10.1097/MD.0000000000035521. Medicine (Baltimore). 2023. PMID: 37832082 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
