Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience
- PMID: 17959327
- DOI: 10.1016/j.braindev.2007.09.004
Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience
Abstract
Purpose: To evaluate the efficacy and safety of zonisamide (ZNS) as long-term adjunctive therapy in children with Lennox-Gastaut syndrome (LGS).
Method: We evaluated the seizure frequency, cognitive outcomes, and side effects of 62 LGS patients maintained on ZNS for at least 12 months in three tertiary centers.
Results: Of the 62 LGS patients maintained on ZNS, 3 (4.8%) had 100% seizure control; 14 (22.6%) had >75% to <100% reduction in seizure frequency; 15 (24.2%) had >50% to <75% reduction in seizure frequency; 6 (9.7%) had >0% to <50% reduction in seizure frequency, and 24 (38.7%) had no seizure reduction. Seizure outcomes were not related to seizure types or etiologies. Adverse events included somnolence and anorexia, but all were transient and successfully managed by careful follow-up.
Conclusion: Our results indicate that adjunctive treatment with ZNS is safe and effective in pediatric LGS patients.
Similar articles
-
Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy.Brain Dev. 2010 Mar;32(3):208-12. doi: 10.1016/j.braindev.2009.02.003. Epub 2009 Mar 21. Brain Dev. 2010. PMID: 19304420 Clinical Trial.
-
Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide.Epilepsy Behav. 2006 May;8(3):522-6. doi: 10.1016/j.yebeh.2006.02.001. Epub 2006 Mar 20. Epilepsy Behav. 2006. PMID: 16542880
-
Efficacy and prognosis of a short course of prednisolone therapy for pediatric epilepsy.Eur J Paediatr Neurol. 2008 Jul;12(4):314-20. doi: 10.1016/j.ejpn.2007.09.003. Epub 2007 Oct 22. Eur J Paediatr Neurol. 2008. PMID: 17951084 Clinical Trial.
-
Practical prescribing and long-term efficacy and safety of zonisamide.Epilepsy Res. 2006 Feb;68 Suppl 2:S17-24. doi: 10.1016/j.eplepsyres.2005.11.006. Epub 2006 Jan 9. Epilepsy Res. 2006. PMID: 16406743 Review.
-
Zonisamide in the management of epilepsy--Japanese experience.Epilepsy Res. 2006 Feb;68 Suppl 2:S25-33. doi: 10.1016/j.eplepsyres.2005.11.007. Epilepsy Res. 2006. PMID: 16321507 Review.
Cited by
-
Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies.CNS Drugs. 2021 Jan;35(1):61-83. doi: 10.1007/s40263-020-00784-8. Epub 2021 Jan 21. CNS Drugs. 2021. PMID: 33479851 Free PMC article. Review.
-
Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions.Neuropsychiatr Dis Treat. 2017 Apr 20;13:1131-1140. doi: 10.2147/NDT.S115996. eCollection 2017. Neuropsychiatr Dis Treat. 2017. PMID: 28461749 Free PMC article. Review.
-
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies.CNS Drugs. 2022 Oct;36(10):1079-1111. doi: 10.1007/s40263-022-00955-9. Epub 2022 Oct 4. CNS Drugs. 2022. PMID: 36194365 Free PMC article. Review.
-
Management of seizures in Lennox-Gastaut syndrome.Paediatr Drugs. 2011 Apr 1;13(2):107-18. doi: 10.2165/11536940-000000000-00000. Paediatr Drugs. 2011. PMID: 21351810 Review.
-
Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy.Acta Epileptol. 2023 Jun 28;5(1):16. doi: 10.1186/s42494-023-00127-2. Acta Epileptol. 2023. PMID: 40217485 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
