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. 2007 Aug 17;12(8):1900-9.
doi: 10.3390/12081900.

Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds

Norbert Haider  1 , Tamara Kabicher, Johann Käferböck, Angelika Plenk
Affiliations

Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds

Norbert Haider et al. Molecules. .

Abstract

A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.

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Figures

Figure 1
Figure 1
Structures of the alkaloids, ellipticine and olivacine.
Scheme 1
Scheme 1
Synthesis of bridged ellipticine/olivacine analogs [9].
Scheme 2
Scheme 2
Synthesis of the target compounds (3) by Sonogashira cross-coupling.
See this image and copyright information in PMC

References

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