Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Aug 17;12(8):1910-39.
doi: 10.3390/12081910.

Biological activities of hydrazone derivatives

Sevim Rollas  1 , S Güniz Küçükgüzel
Affiliations
Review

Biological activities of hydrazone derivatives

Sevim Rollas et al. Molecules. .

Abstract

There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
Scheme 2
Scheme 2
Scheme 3
Scheme 3
Scheme 4
Scheme 4
Scheme 5
Scheme 5
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rollas S., Gülerman N., Erdeniz H. Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines. Farmaco. 2002;57:171–174. doi: 10.1016/S0014-827X(01)01192-2. - DOI - PubMed
    1. Küçükgüzel Ş.G., Rollas S., Küçükgüzel İ, Kiraz M. Synthesis and Antimycobacterial activity of some coupling products from 4-aminobenzoic acid hydrazones. Eur. J. Med. Chem. 1999;34:1093–1100.
    1. Küçükgüzel Ş.G., Oruç E.E., Rollas S., Şahin F., Özbek A. Synthesis, Characterization and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds. Eur. J. Med. Chem. 2002;37:197–206. - PubMed
    1. Kaymakçıoğlu K.B., Oruç E.E., Unsalan S., Kandemirli F., Shvets N., Rollas S., Anatholy D. Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. Eur. J. Med. Chem. 2006;41:1253–1261. - PubMed
    1. Sah P.P.T., Peoples S.A. Isonicotinyl hydrazones as antitubercular agents and derivatives for idendification of aldehydes and ketones. J. Am. Pharm. Assoc. 1954;43:513–524. doi: 10.1002/jps.3030430902. - DOI - PubMed

LinkOut - more resources