Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct;8(10):1264-9.
doi: 10.1023/a:1015899612117.

Solution stability of the monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB

A Riggin  1 , D Clodfelter, A Maloney, E Rickard, E Massey
Affiliations

Solution stability of the monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB

A Riggin et al. Pharm Res. 1991 Oct.

Abstract

A 3-month solution stability study at 5 degrees C of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB indicated that phosphate-buffered saline solutions at pH 4.5-5.5 had little tendency to lose vinca by hydrolysis, improved vinca stability, showed acceptable physical stability, and formed minimal amounts of soluble aggregates compared to solutions at pH 6.5-7.4. Hydrolysis and aggregation with concomitant loss of stability were accelerated at 30 degrees C throughout the pH range investigated. As determined by ELISA, the binding properties of KS1/4-DAVLB to tumor antigens were not affected by pH or temperature. A formulation suitable for initial clinical trials in cancer patients is described.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biotechnol Appl Biochem. 1988 Dec;10(6):536-44 - PubMed
    1. Biotechniques. 1988 Nov-Dec;6(10 ):982-92 - PubMed
    1. Cancer Immunol Immunother. 1986;21(3):183-7 - PubMed
    1. J Pharmacol Exp Ther. 1987 May;241(2):695-703 - PubMed
    1. Targeted Diagn Ther. 1988;1:55-79 - PubMed

LinkOut - more resources