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Comparative Study
. 2007 Nov;44(Pt 6):512-5.
doi: 10.1258/000456307782268200.

Serum free light chains; the need to establish local reference intervals

Rebecca J Pattenden  1 , Stephen Y Rogers, Philip R Wenham
Affiliations
Comparative Study

Serum free light chains; the need to establish local reference intervals

Rebecca J Pattenden et al. Ann Clin Biochem. 2007 Nov.

Abstract

Background: The purpose of this study was to compare The Binding Site serum free light chain assay on two analytical platforms; the Dade Behring BNII and the Olympus AU400. Reference intervals were subsequently established on each analyser.

Methods: In total, 112 serum samples routinely submitted to the laboratory for protein electrophoresis were used for the comparison study. Reference interval data was generated from 126 ostensibly healthy anonymous individuals.

Results: Serum free light chain results on the BNII and AU400 analysers are not directly comparable. The BNII produces results which are significantly higher than the AU400.

Conclusions: Laboratories using The Binding Site serum free light chain assay are strongly advised to establish local reference intervals.

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Comment in

  • Free light chains.
    Sheldon J. Sheldon J. Ann Clin Biochem. 2007 Nov;44(Pt 6):503-5. doi: 10.1258/000456307782268183. Ann Clin Biochem. 2007. PMID: 17961302 No abstract available.

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