How different is oxycodone from morphine?

doi:10.1016/j.pain.2007.09.027

Review

. 2007 Dec 5;132(3):227-228.

doi: 10.1016/j.pain.2007.09.027. Epub 2007 Oct 24.

How different is oxycodone from morphine?

Eija Kalso¹

Affiliations

Affiliation

¹ Institutes of Clinical Medicine and Biomedicine, University of Helsinki, Helsinki, Finland Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P.O. Box 140, 00029 HUS, Finland.

PMID: 17961923
DOI: 10.1016/j.pain.2007.09.027

Review

How different is oxycodone from morphine?

Eija Kalso. Pain. 2007.

. 2007 Dec 5;132(3):227-228.

doi: 10.1016/j.pain.2007.09.027. Epub 2007 Oct 24.

Author

Eija Kalso¹

Affiliation

¹ Institutes of Clinical Medicine and Biomedicine, University of Helsinki, Helsinki, Finland Pain Clinic, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, P.O. Box 140, 00029 HUS, Finland.

PMID: 17961923
DOI: 10.1016/j.pain.2007.09.027

No abstract available

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Comment on

Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain.
Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Nielsen CK, et al. Pain. 2007 Dec 5;132(3):289-300. doi: 10.1016/j.pain.2007.03.022. Epub 2007 Apr 30. Pain. 2007. PMID: 17467904

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References

1. Beardsley PM, Aceto MD, Cook CD, Bowman ER, Newman JL, Harris LS. Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys. Exp Clin Psychopharm. 2004;12:163-172.
1. Boström E, Simonsson USH, Hammarlund-Udenaes M. In vivo blood–brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drugs Metab Dispos. 2006;34:1624-1631.
1. Corbett AD, Henderson G, McKight AT, Paterson SJ. 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol. 2006;147:S153-S162.
1. Devi LA. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci. 2001;22:532-537.
1. Eisenberg E, McNicol ED, Carr DB. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. JAMA. 2005;293:3043-3052.

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[1] Beardsley PM, Aceto MD, Cook CD, Bowman ER, Newman JL, Harris LS. Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys. Exp Clin Psychopharm. 2004;12:163-172.

[2] Beardsley PM, Aceto MD, Cook CD, Bowman ER, Newman JL, Harris LS. Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys. Exp Clin Psychopharm. 2004;12:163-172.

[3] Boström E, Simonsson USH, Hammarlund-Udenaes M. In vivo blood–brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drugs Metab Dispos. 2006;34:1624-1631.

[4] Boström E, Simonsson USH, Hammarlund-Udenaes M. In vivo blood–brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drugs Metab Dispos. 2006;34:1624-1631.

[5] Corbett AD, Henderson G, McKight AT, Paterson SJ. 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol. 2006;147:S153-S162.

[6] Corbett AD, Henderson G, McKight AT, Paterson SJ. 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol. 2006;147:S153-S162.

[7] Devi LA. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci. 2001;22:532-537.

[8] Devi LA. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci. 2001;22:532-537.

[9] Eisenberg E, McNicol ED, Carr DB. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. JAMA. 2005;293:3043-3052.

[10] Eisenberg E, McNicol ED, Carr DB. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. JAMA. 2005;293:3043-3052.

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How different is oxycodone from morphine?

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