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Comparative Study
. 2008 Jan;98(1-3):307-11.
doi: 10.1016/j.schres.2007.05.011. Epub 2007 Oct 25.

Obstetrical complications in people at risk for developing schizophrenia

Jacob S Ballon  1 , Katherine A Dean, Kristin S Cadenhead
Affiliations
Comparative Study

Obstetrical complications in people at risk for developing schizophrenia

Jacob S Ballon et al. Schizophr Res. 2008 Jan.

Abstract

Many factors have been associated with the development of schizophrenia, yet few studies have looked at these same factors in individuals considered at risk for schizophrenia, but who have not yet reached diagnostic threshold. The rate of obstetrical complications was assessed as part of a comprehensive battery in subjects at risk (N=52), or in the first episode of schizophrenia (N=18), and in normal comparison subjects (N=43). The rate of obstetrical complications was increased in the at risk (46%) and first episode (39%) samples compared to the normal comparison (19%) group, however, follow-up analyses were only significant between the at risk and normal comparison subjects. Obstetrical complications may be an important risk factor in identifying vulnerable subjects and ultimately may, along with other risk factors, be part of an algorithm for determining likelihood of developing schizophrenia.

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References

    1. Andreasen NC, Endicott J, Spitzer RL, Winokur G. The family history method using diagnostic criteria: reliability and validity. Archives of General Psychiatry. 1977;34:1229–1235. - PubMed
    1. Brown AS, Begg MD, Gravenstein S, et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. 2004;61:774–780. - PubMed
    1. Brown AS, Schaefer CA, Wyatt RJ, et al. Paternal age and risk of schizophrenia in adult offspring. Am J Psychiatry. 2002;159:1528–1533. - PMC - PubMed
    1. Cadenhead KS. Vulnerability markers in the schizophrenia spectrum: implications for phenomenology, genetics, and the identification of the schizophrenia prodrome. Psychiatr Clin North Am. 2002;25:837–853. - PubMed
    1. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159:1080–1092. - PubMed

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