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Comparative Study
. 2008 Jan;98(1-3):111-7.
doi: 10.1016/j.schres.2007.09.020. Epub 2007 Oct 24.

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection

Rajiv P Sharma  1 , Dennis R Grayson, David P Gavin
Affiliations
Comparative Study

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection

Rajiv P Sharma et al. Schizophr Res. 2008 Jan.

Abstract

Histone deactylase enzymes are responsible for the deacetylation of histone tails, and consequently influence gene regulation through their ability to modify chromatin structure surrounding promoter regions. We analyzed the microarray collection of the National Brain Databank to investigate differential expression of these enzymes in the prefrontal cortices of control, schizophrenia and bipolar subjects. HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. These findings provide additional support for the proposal that epigenetic factors are operative in the brain pathology of patients with schizophrenia.

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Figures

Figure 1
Figure 1. Histone Deactylase-1 is increased in the prefrontal cortex of schizophrenia subjects
A restricted analysis (on the identified genes in the text) was conducted using the microarray collection of the National Brain Databank. Expression of HDAC enzymes in samples of postmortem prefrontal cortical tissue was compared between the diagnostic groups as presented. There is a significant increase in HDAC1 expression levels in samples obtained from schizophrenia subjects compared to controls.
Figure 2
Figure 2. HDAC1 and GAD 67 mRNA expression levels are correlated in the prefrontal cortex
GAD 67 is an epigenetically controlled gene whose regulation is influenced by the level of acetylated (increased expression) or deacetylated chromatin (decreased expression) that surrounds its promoter sequence. There was a significant correlation between HDAC1 and GAD67 expression signals in 64 subjects (Controls=27, Bipolar=16, Schizophrenia=18, Schizoaffective=3)
See this image and copyright information in PMC

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