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. 2007 Aug 30;12(9):2123-9.
doi: 10.3390/12092123.

Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification

Kai Bao  1 , Weige Zhang, Chuanliang Zhang, Yingwei Qu, Liang Tian, Lan Wu, Xiang Zhao, Maosheng Cheng
Affiliations

Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification

Kai Bao et al. Molecules. .

Abstract

The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.

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Figures

Scheme 1
Scheme 1
The synthetic route for compounds 2a-2g.
See this image and copyright information in PMC

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