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Review
. 2007 Jun;32(3):201-9.
doi: 10.1007/s12016-007-8002-9.

Horizons in Sjögren's syndrome genetics

Pamela H Williams  1 , Beth L Cobb, Bahram Namjou, R Hal Scofield, Amr H Sawalha, John B Harley
Affiliations
Review

Horizons in Sjögren's syndrome genetics

Pamela H Williams et al. Clin Rev Allergy Immunol. 2007 Jun.

Abstract

Sjögren's syndrome (SS) is a complex polygenic autoimmune disorder. A few major genetic effects have been identified. Historically, HLA and non-HLA genetic associations have been reported. Recently, the HLA region continued to reveal association findings. A new susceptibility region has been suggested by a study of a D6S349 microsatellite marker. Among non-HLA studies, recent association of immunoglobulin kappa chain allotype KM1 with anti-La autoantibodies in primary Sjögren's syndrome confirms findings in a study from two decades ago. Meanwhile, mouse models have been employed to study the genetic contribution to salivary lymphadenitis or dry eyes and mouth. Gene transfer exploration in mouse models shows promise. The authors review the HLA and non-HLA association studies and the mouse model work that has been reported. Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren's syndrome.

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Figures

Fig. 1
Fig. 1
The human leukocyte antigen (HLA) allele reported to have associations with primary Sjögren’s syndrome. Confirmed associations are in bold type
See this image and copyright information in PMC

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