[Interspecies mouse-mink hybridomas as producers of mink immunoglobulin]
- PMID: 1796509
[Interspecies mouse-mink hybridomas as producers of mink immunoglobulin]
Abstract
The work is aimed at establishing the interspecies mouse-mink hybridomas from the fusion of American mink B-lymphocytes with the murine cell line NSO. The hybridoma (lime 10-B5) continued to secrete mink immunoglobulin L-chains in the culture for 6 months with constant reclonings. The hybridoma clone was characterized by a decrease in the secretory activity of cells. The karyological study et this clone has not reliably revealed the mink chromosomes in the genome of hybrid cells.
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