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. 2008 Jan;36(Database issue):D646-50.
doi: 10.1093/nar/gkm936. Epub 2007 Oct 26.

CORUM: the comprehensive resource of mammalian protein complexes

Andreas Ruepp  1 , Barbara Brauner, Irmtraud Dunger-Kaltenbach, Goar Frishman, Corinna Montrone, Michael Stransky, Brigitte Waegele, Thorsten Schmidt, Octave Noubibou Doudieu, Volker Stümpflen, H Werner Mewes
Affiliations

CORUM: the comprehensive resource of mammalian protein complexes

Andreas Ruepp et al. Nucleic Acids Res. 2008 Jan.

Abstract

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.

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Figures

Figure 1.
Figure 1.
Overview about the FunCat functional annotation results of the protein complexes in CORUM. The different search options of the database are also shown.
Figure 2.
Figure 2.
Result page of the Ubiquitin E3 ligase (containing FBXW7, CUL1, SKP1A and RBX1) protein complex from the CORUM database.
See this image and copyright information in PMC

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