Review
doi: 10.4161/epi.2.1.3697.
Epub 2006 Dec 12.
The Odyssey of MeCP2 and parental imprinting
Affiliations
- PMID: 17965611
- PMCID: PMC1866173
- DOI: 10.4161/epi.2.1.3697
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Review
The Odyssey of MeCP2 and parental imprinting
Epigenetics.
2007 Jan-Mar.
Abstract
DNA methylation in mammals has long been implicated in the epigenetic mechanism of parental imprinting, in which selective expression of one allele of specific genes is based on parental origin. Methyl CpG binding protein 2 (MeCP2) selectively binds to methylated DNA and mutations in the MECP2 cause the autism-spectrum neurodevelopmental disorder Rett syndrome. This review outlines the emerging story of how MeCP2 has been implicated in the regulation of specific imprinted genes and loci, including UBE3A and DLX5. The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process.
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References
-
- McGrath J, Solter D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell. 1984;37:179–183. - PubMed
-
- Barlow DP. Gametic imprinting in mammals. Science. 1995;270:1610–1613. - PubMed
-
- Razin A, Cedar H. DNA methylation and genomic imprinting. Cell. 1994;77:473–476. - PubMed
-
- Lewis JD, Meehan RR, Henzel WJ, Maurer-Fogy I, Jeppesen P, Klein F, Bird A. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell. 1992;69:905–914. - PubMed
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