Review
doi: 10.1038/nri2204.
BLIMP1 guides the fate of effector B and T cells
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- PMID: 17965637
- DOI: 10.1038/nri2204
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Review
BLIMP1 guides the fate of effector B and T cells
Nat Rev Immunol.
2007 Dec.
Abstract
B-lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor, and its importance in controlling the terminal differentiation of antibody-secreting cells (ASCs) is well established. However, as we discuss in this Progress article, it has now become evident that the ASC programme consists of a discrete BLIMP1-independent initiation phase, followed by a second step in which BLIMP1 is absolutely required for the differentiation of fully mature ASCs. In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells.
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