Review
doi: 10.2478/s11658-007-0046-6.
Epub 2008 Apr 10.
Natriuretic peptides in cardiovascular diseases
Affiliations
- PMID: 17965966
- PMCID: PMC6275881
- DOI: 10.2478/s11658-007-0046-6
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Review
Natriuretic peptides in cardiovascular diseases
Cell Mol Biol Lett.
2008.
Abstract
The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.
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