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. 2007 Nov;40(2):135-43.
doi: 10.1016/j.cyto.2007.08.012. Epub 2007 Oct 29.

Evaluation of the changes of immune cells during lipopolysaccharide-induced mastitis in rats

Jin-Feng Miao  1 , Yu-Min Zhu, Bei-Bei Gu, Xiao-Bin Wang, Si-Xiang Zou, Yue-E Deng
Affiliations

Evaluation of the changes of immune cells during lipopolysaccharide-induced mastitis in rats

Jin-Feng Miao et al. Cytokine. 2007 Nov.

Abstract

The aim of this study was to evaluate in rats, changes in peripheral blood immune cells and mammary tissue after an intramammary infusion of lipopolysaccharide (LPS). The results of the study showed that infusion of LPS induced a rapid migration of neutrophils (PMNs) from the blood to mammary alveoli, increased the activity of myeloperoxidase (MPO) and the concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in mammary tissues, decreased the activity of myeloperoxidase in serum and reduced the CD4+/CD8+ ratio. This is the first report of changes in peripheral blood immune cells and mammary tissue in rat mastitis.

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